Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M19155 | Entadamide A | Entadamide A is a natural product found in Entada rheedei and Entada gigas. Entadamide A inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml. |
| M15061 | Atuliflapon | Atuliflapon (AZD5718) is a 5-lox activating protein (FLAP, 5‑Lipoxygenase activating protein) inhibitor that attenuates the 5-lipoxygenase pathway and reduces pro-inflammatory and vasoactive leukotriene (LT) production at an in vitro maximum 50% inhibitory concentration (IC50) of 39nM. |
| M14460 | ML355 | ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. |
| M11119 | 11-Keto-beta-boswellic acid | 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenoid acid derived from the oleoresin of the bark of the Boswellia serrate tree commonly known as Indian Frankincense. 11-Keto-beta-boswellic acid has anti-inflammatory activity, mainly due to inhibition of 5-lipoxygenase (5-lipoxygenase; Activation of 5-LOX), leukotriene, activation of NF-κB and production of tumor necrosis factor α. |
| M10499 | FPL 62064 | FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. |
| M9133 | AKBA | AKBA is an active triterpenoid compound from the extract of Boswellia serrata and Boswellia carteri Birdw, exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase. |
| M8506 | ML351 | ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. |
| M7964 | Nordihydroguaiaretic acid | Nordihydroguaiaretic acid (NDGA) is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor. |
| M6331 | 2-TEDC | 2-TEDC is a 5-, 12-, 15-Lipoxygenase inhibitor. |
| M4714 | Picrinine | Picrinine is an Akuammiline alkaloid isolated from the leaves of Alstonia Scholaris. Picrinine shows anti-inflammatory activity by inhibiting 5-lipoxygenase. |
| M3728 | MK 886 | Mk-886 (L 663536) is a potent, cellular permeable, orally active inhibitor of FLAP (IC50 at 30 nM) and leukotriene biosynthesis (IC50 at 3 nM and 1.1μM in whole white blood cells and human whole blood, respectively). Mk-886 is also a non-competitive PPARα antagonist that can induce apoptosis. |
| M2733 | GSK2190915 | GSK2190915 (AM803), a potent FLAP inhibitor, prevents the synthesis of leukotrienes and 5-oxo-ETE, with IC50 of 76 nM for inhibition of LTB4 in human blood, provides treatment for asthma. |
| M2332 | Zileuton | Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis with IC50 values of 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively. |
| M2222 | Malotilate | Malotilate is a hepatoprotective agent used in the treatment of liver disease. |
| M56711 | 5-LOX-IN-1 | 5-LOX-IN-1 is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. |
| M56710 | Aureusidin | Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. |
| M56709 | Sclerotiorin | Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). |
| M45337 | ALOX15-IN-2 | ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively. |
| M44786 | Atractylochromene | Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively. |
| M42490 | 5-LOX-IN-5 | 5-LOX-IN-5 is a 5-LOX inhibitor (IC50: 56 nM). |
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