Inhibitor
| Cat.No. | Name | Information |
|---|---|---|
| M42489 | EP6 | EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. |
| M42488 | Patulitrin | Patulitrin has scavenging effect in the DPPH radical. |
| M42487 | 5-LOX-IN-3 | 5-LOX-IN-3 is a 5-Lipoxygenase inhibitor (IC50: <1 μM). |
| M42486 | KKII5 | KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. |
| M42485 | COX-2/15-LOX-IN-4 | COX-2/15-LOX-IN-4 is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. |
| M42484 | COX-2/15-LOX-IN-3 | COX-2/15-LOX-IN-3 is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. |
| M42483 | MLS000545091 | MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2. |
| M42482 | h15-LOX-2 inhibitor 1 | h15-LOX-2 inhibitor 1 is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC50 of 0.34 μM. |
| M42481 | 5-LOX-IN-2 | 5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . |
| M42005 | COX-2/15-LOX-IN-2 | COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065?μM and 1.86?μM, respectively. |
| M39157 | Plathymenin | Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of 5-LOX. |
| M39156 | 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone | 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone, isolated from Parinari hypochrysea (Chrysobalanaceae), exhibits antioxidant and lipoxygenase inhibition. |
| M29823 | Masoprocol | Masoprocol is a potent, orally active lipoxygenase inhibitor and Nrf2 pathway activator that reduces glucose and hepatic triglyceride concentrations in vivo, and has antihyperglycemic activity that may be useful in studies related to type II diabetes. |
| M28508 | Quiflapon sodium | Quiflapon sodium (MK-591 sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Quiflapon sodium is an orally active Leukotriene biosynthesis inhibitor. Induces apoptosis. |
| M28263 | Quiflapon | Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis. |
| M17998 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid | 3-O-Acetyl-11-hydroxy-beta-boswellic acid |
| M14459 | Docebenone | Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. |
| M14458 | 5-O-Demethylnobiletin | 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. |
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