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MLS000545091

Cat. No. M42483

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MLS000545091 Structure

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Quality Control & Documentation
Biological Activity

MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2.

Chemical Information
Molecular Weight 262.73
Formula C14H15ClN2O
CAS Number 322666-76-2
Form Solid
Solubility (25°C) DMSO 20 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Wan-Chen Tsai et al. Bioorg Med Chem. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2

[2] J Brian Jameson 2nd et al. PLoS One. A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2

Related Lipoxygenase Products
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5-LOX-IN-1 is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM.

Aureusidin 

Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity.

Sclerotiorin

Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM).

ALOX15-IN-2

ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively.

Atractylochromene

Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: MLS000545091 supplier, Lipoxygenase, inhibitors, activators

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