Free shipping on all orders over $ 500

COX-2/15-LOX-IN-4

Cat. No. M42485
COX-2/15-LOX-IN-4 Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

COX-2/15-LOX-IN-4 is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively.

Chemical Information
Molecular Weight 405.49
Formula C23H20FN3OS
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ali Aliabadi et al. Eur J Med Chem. Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer

[2] Amany M Ghanim et al. Eur J Med Chem. Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition

[3] Rana A Alaaeddine et al. Curr Med Chem. The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs)

[4] Bahaa G M Youssif et al. Bioorg Chem. Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

[5] Yasser M Omar et al. Bioorg Chem. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX

Related Lipoxygenase Products
ALOX15-IN-2

ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively.
Atractylochromene

Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively.
5-LOX-IN-5

5-LOX-IN-5 is a 5-LOX inhibitor (IC50: 56 nM).
EP6

EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor.
Patulitrin

Patulitrin has scavenging effect in the DPPH radical.
  Catalog
Abmole Inhibitor Catalog




Keywords: COX-2/15-LOX-IN-4 supplier, Lipoxygenase, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.