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FPL 62064

Cat. No. M10499
FPL 62064 Structure
Synonym:

FPL62064

Size Price Availability Quantity
5mg USD 150  USD150 In stock
25mg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. In vivo, FPL 62064 (5-20 mg/kg; intraperitoneal injection) treatment on female LACA mice inhibits peritoneal inflammation induced by immune-complex.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 265.31
Formula C16H15N3O
CAS Number 103141-09-9
Purity >98.5%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

[1] Mohamed A Shabaan, et al. Arch Pharm (Weinheim). Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase

[2] A Blackham, et al. Agents Actions. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: FPL 62064, FPL62064 supplier, Lipoxygenase, inhibitors

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