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FPL 62064

Cat. No. M10499
FPL 62064 Structure
Synonym:

FPL62064

Size Price Availability Quantity
5mg USD 150  USD150 In stock
25mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. In vivo, FPL 62064 (5-20 mg/kg; intraperitoneal injection) treatment on female LACA mice inhibits peritoneal inflammation induced by immune-complex.

Chemical Information
Molecular Weight 265.31
Formula C16H15N3O
CAS Number 103141-09-9
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohamed A Shabaan, et al. Arch Pharm (Weinheim). Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase

[2] A Blackham, et al. Agents Actions. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor

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Keywords: FPL 62064, FPL62064 supplier, Lipoxygenase, inhibitors, activators


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