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11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenoid acid derived from the oleoresin of the bark of the Boswellia serrate tree commonly known as Indian Frankincense. 11-Keto-beta-boswellic acid has anti-inflammatory activity, mainly due to inhibition of 5-lipoxygenase (5-lipoxygenase; Activation of 5-LOX), leukotriene, activation of NF-κB and production of tumor necrosis factor α.
| Molecular Weight | 470.68 |
| Formula | C30H46O4 |
| CAS Number | 17019-92-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related Lipoxygenase Products |
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| 5-LOX-IN-1
5-LOX-IN-1 is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. |
| Aureusidin
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. |
| Sclerotiorin
Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). |
| ALOX15-IN-2
ALOX15-IN-2 is a potent inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50s of 1.55 and 2.79 μM for linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, respectively. |
| Atractylochromene
Atractylochromene is a potent dual inhibitor of 5-LOX/COX-1 with IC50s of 0.6 and 3.3 μM, respectively. |
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