About 30 results found for searched term "BIO" (0.012 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1831 | Cyclosporine A | Immunology/Inflammation |
| Ciclosporin A; CsA; Cyclosporin A; Antibiotic S 7481F1 | ||
| Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. | ||
| M2026 | AT-406 | IAP |
| SM-406; Xevinapant; Debio 1143 | ||
| Xevinapant (Debio1143,AT-406, SM-406) is a potentially first-in-class, highly potent oral antagonist of inhibitor of apoptosis protein (IAP), which not only promotes cancer cell death by inhibiting IAP, but also It can enhance the anti-tumor immune response by inhibiting IAP. | ||
| M2213 | Ki16425 | LPL Receptor |
| Debio 0719 | ||
| Ki16425 is a LPA receptor antagonist with Ki values of 0.34, 6.5 and 0.93 μM for the human LPA1, LPA2 and LPA3 receptors, respectively. | ||
| M2456 | Biotin | Others |
| Vitamin B7; Vitamin H; D-Biotin | ||
| Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. | ||
| M2790 | K252a | PKC |
| SF 2370; Antibiotic K-252a; Antibiotic SF 2370 | ||
| K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. | ||
| M9918 | Lentinan | Adjuvants |
| Biomoduline | ||
| Lentinan is purified β-glucan from Shiitake mushrooms, also used as adjuvant. | ||
| M4044 | Formononetin | FGFR |
| Biochanin B; Flavosil; Formononetol | ||
| Formononetin is a bioactive component extracted from the red clover. | ||
| M4120 | Scabioside-C | Others |
| Scabioside C is the main triterpenoid saponins of total secondary saponins (TSS). TSS comes from A. Raddeana and has potential anti-breast cancer effects. | ||
| M4693 | Biochanin-A | FAAH |
| 4-Methylgenistein; Olmelin | ||
| Biochanin A is A naturally occurring fatty acid amide hydrolase (FAAH) inhibitor that inhibits FAAH in mice, rats and humans with FAAH IC50 of 1.8, 1.4 and 2.4 μM, respectively. | ||
| M4924 | Dehydroacetic acid | Antibiotic |
| Biocide 470F | ||
| Dehydroacetic acid is an organic compound, classified as a pyrone derivative and is used mostly as a fungicide and bactericide. | ||
| M5272 | Bioymifi | TNF Receptor |
| DR5 Activator | ||
| Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. | ||
| M5318 | Zoligratinib | EGFR/HER2 |
| CH5183284;Debio 1347 | ||
| CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1. | ||
| M5451 | Benzyl benzoate | Parasite |
| Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester | ||
| Benzyl benzoate is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. | ||
| M5825 | Novobiocin Sodium | Topoisomerase |
| Albamycin; Cathomycin | ||
| Novobiocin Sodium is an aminocoumarin antibiotic that targets bacterial DNA gyrase (TopoIV), used to treat susceptible gram positive bacteria. | ||
| M6292 | Ansamitocin P 3 | Microtubule |
| Antibiotic C 15003P3; Maytansinol butyrate | ||
| Ansamitocin P-3 is a microtubule inhibitor, it is also a macrocyclic antitumor antibiotic. | ||
| M6323 | 1-EBIO | Potassium Channel |
| 1-EBIO is a activator of epithelial K Ca channels. | ||
| M6508 | BIO5192 | Integrin |
| BIO-5192 | ||
| BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. | ||
| M6509 | Biocytin | Metabolite/Endogenous Metabolite |
| (+)-Biocytin | ||
| Biocytin is a versatile marker for neuroanatomical investigations. | ||
| M6657 | DCEBIO | Others |
| DCEBIO is a activates Cl- conductance and hKCa3.1 channels. | ||
| M7627 | BIO | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | ||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific GSK-3 inhibitor, the IC50 acting on GSK-3α/β in cell-free assays is 5 nM, which is more than 16 times more selective than ACTing on CDK5. It is also a pan-JAK inhibitor with an IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. | ||
| M8385 | BIO-Acetoxime | GSK-3 |
| BIA | ||
| BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. | ||
| M8417 | Geldanamycin-Biotin | Others |
| Geldanamycin-Biotin is a benzoquinone ansamycin antitumor antibiotic. | ||
| M8789 | Biotinyl tyramide | Others |
| Biotinyl tyramide is a reagent used for tyramide signal amplification for both immunohistochemistry (IHC) and in situ hybridiztion protocols and with either chromogenic or fluorescence detection. | ||
| M9378 | NHS-Biotin | Others |
| Biotin N-hydroxysuccinimide ester | ||
| NHS-Biotin is an amine reactive biotinylation reagent, used in the biotinylation of proteins and peptides. | ||
| M9504 | D-Desthiobiotin | Metabolite/Endogenous Metabolite |
| Dethiobiotin | ||
| D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation. | ||
| M9780 | Nigericin | Potassium Channel |
| Antibiotic K178, Antibiotic X464 | ||
| Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. | ||
| M9860 | Bleomycin A5 Hydrochloride | DNA/RNA Synthesis |
| BLEOCIN Antibiotic; Bleomycin A5 HCl | ||
| Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. | ||
| M10072 | AFN-1252 | Antibiotic |
| API-1252; Debio 1452 | ||
| AFN-1252 (API-1252; Debio-1452) is an enoyl-(acyl-carrier protein) reductase fabl inhibitor. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. | ||
| M10075 | (+)-Biotinamidohexanoic acid hydrazide | Others |
| Biotin LC hydrazide | ||
| Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins. | ||
| M10712 | BIO-013077-01 | TGF-beta/Smad |
| BIO-013077-01 is a Pyrazole inhibitor of TGF-β. | ||
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