About 30 results found for searched term "BA 1" (0.012 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2040 | BAY 11-7082 | IκB/IKK |
| BAY 11-7821; NF-κB inhibitor 13 | ||
| BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). | ||
| M2240 | Acarbose | Glucosidase |
| Prandase, Precose, BAY g 5421 | ||
| Acarbose (BAY G 5421) is an alpha-glucosidase inhibitor with oral activity (IC50=11 nM). Acarbose can enhance the hypoglycemic effect of sulfonylurea inhibitors or insulin. | ||
| M2313 | Tirbanibulin (KX2-391) | Src-bcr-Abl |
| KX-01 | ||
| Tirbanibulin (KX2-391) is a First-in-Class, highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines . | ||
| M2386 | Amikacin disulfate | Others |
| BAY 41-6551 sulfate; BB-K8 | ||
| Amikacin sulfate binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis. | ||
| M2428 | BAF312 | S1P Receptor |
| Siponimod | ||
| BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. | ||
| M2434 | BAY 1000394 | CDK |
| Roniciclib | ||
| BAY 1000394 is an orally bioavailable pan-CDK inhibitor for CDK1/2/3/4/7/9 with IC50 of 5-25 nM. It also potently inhibits Aurora A, Clk2, ARK5, FGFR1, Flt3, and JAK2/3. Phase 1/2. | ||
| M2435 | Bay 11-7085 | IκB/IKK |
| Bay 11-7083 | ||
| BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. | ||
| M2668 | Enrofloxacin | Antibiotic |
| BAY-Vp2674; PD160788 | ||
| Enrofloxacin (BAY Vp 2674) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin is classified under the second generation quinolone antibiotics, known as ′fluoroquinolones′. | ||
| M5240 | BAR 501 impurity | CGRP Receptor |
| M3169 | Lofexidine hydrochloride | Adrenergic Receptor |
| Baq-168; MDL-14042 | ||
| Lofexidine hydrochloride is an selective α2A-adrenergic receptor agonist. | ||
| M3424 | Nifedipine | Calcium Channel |
| BAY-a-1040 | ||
| Nifedipine (BAY-a-1040) is a potent vasodilator agent with calcium antagonistic action. | ||
| M3514 | Moxifloxacin hydrochloride | Topoisomerase |
| BAY12-8039 HCl | ||
| Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent. | ||
| M45341 | Ajulemic acid | Cannabinoid |
| Lenabasum; IP 751 | ||
| Ajulemic acid is a synthetic, orally available Δ9-tetrahydrocannabinol metabolite and cannabinoid receptor agonist with Ki values of 5.7 nM for hCB1 and 56.1 nM for hCB2, and EC50 values of 11.6 nM and 13.4 nM, respectively. | ||
| M3633 | Refametinib | MEK |
| BAY 86-9766, RDEA119 | ||
| Refametinib (BAY 86-9766, RDEA119) is a potent, highly selective and ATP non-competitive inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively. | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M4450 | Acteoside | PKC |
| Verbascoside; Kusaginin; TJC160 | ||
| Acteoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||
| M4953 | Bafilomycin A1 | Proton Pump |
| Baf-A1；BafA1 | ||
| Bafilomycin A1 (BafA1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. | ||
| M11228 | BAY1125976 | Akt |
| BAY1125976 is an Akt1/Akt2 selective allosteric inhibitor. The IC50 values of Akt1 and Akt2 inhibition at 10 μM ATP were 5.2 nM and 18 nM, respectively. | ||
| M5073 | (R)-(+)-BAY K 8644 | Calcium Channel |
| (R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644; Bayk8644 | ||
| (R)-(+)-BAY K 8644 is a calcium channel inhibitor, inhibits Ba2+ currents (IBa) with IC50 of 975 nM. | ||
| M5077 | (S)-(-)-BAY K 8644 | Calcium Channel |
| (S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644 | ||
| (S)-(-)-BAY K 8644 is a Ca2+ channel activator; L-type Ca2+ channel activator. | ||
| M5223 | BAR501 | CGRP Receptor |
| BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. | ||
| M5224 | Fumagillin | Antibiotic |
| Amebacilin; NSC9168 | ||
| Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. | ||
| M5247 | BAY 61-3606 dihydrochloride | Syk |
| BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). | ||
| M5477 | Carbazochrome sodium sulfonate (AC-17) | Adrenergic Receptor |
| AC-17 | ||
| Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids. | ||
| M5783 | Methylene Blue | Monoamine Oxidase |
| Basic Blue 9; Tetramethylthionine chloride; CI-52015; Methylthioninium chloride | ||
| Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | ||
| M5788 | Miglitol | Others |
| BAY1099; BAY-m1099 | ||
| Miglitol is an oral compound that can be used to study diabetes and inhibits the breakdown of sugar complexes into glucose. | ||
| M5932 | Riociguat (BAY 63-2521) | Guanylate Cyclase |
| BAY 632521 | ||
| Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the research of ipulmonary hypertension. | ||
| M6080 | Elimusertib (BAY-1895344) | ATM/ATR |
| Elimusertib | ||
| Elimusertib (BAY-1895344) is an effective, oral, selective ATR inhibitor with an IC50 value of 7 nM and antitumor activity. Elimusertib (Bay-1895344) showed antitumor activity against A2780 ovarian cancer, PC-3 prostate cancer, LOVO colorectal cancer and REC-1 suite cell lymphoma, and was most sensitive to lymphoma. | ||
| M6172 | Isavuconazole | Antibiotic |
| BAL-4815; RO-0094815 | ||
| Isavuconazole is a moderate inhibitor of CYP3A4 and a water-soluble triazole with broad-spectrum antifungal activity. | ||
| M6212 | BAY-1436032 | Isocitrate Dehydrogenase (IDH) |
| BAY1436032 | ||
| BAY1436032 is a novel pan-mutant IDH1 inhibitor, it specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells. | ||
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