About 17 results found for searched term "Aldosterone" (0.181 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7617 | Aldosterone | Metabolite/Endogenous Metabolite |
| Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorption of Na+. | ||
| M2619 | Deoxycorticosterone acetate | Animal Modeling |
| DOCA; 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate | ||
| Deoxycorticosterone acetate, an adrenocorticotropic hormone and also a precursor of aldosterone, as well as a salicorticoid receptor (MR) agonist, can be used to construct rat models of hypertension. | ||
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M3256 | Eplerenone | Others |
| Epoxymexrenone | ||
| Eplerenone (Epoxymexrenone) is a selective, competitive and oral aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen, and glucocorticoid receptors. Eplerenone may be used in studies of hypertension and heart failure following myocardial infarction. | ||
| M5233 | Osilodrostat | Mineralocorticoid Receptor |
| LCI699 | ||
| Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. | ||
| M5786 | Metyrapone | Metabolite/Endogenous Metabolite |
| Metapirone; Su-4885 | ||
| Metyrapone (Metapirone) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone (Metapirone) inhibits cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. | ||
| M14363 | Deoxycorticosterone | Metabolite/Endogenous Metabolite |
| Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. | ||
| M20441 | Efonidipine | Calcium Channel |
| NZ-105 | ||
| Efonidipine is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal. | ||
| M21321 | SPH3127 | Others |
| SPH3127 is an oral direct renin inhibitor (DRI) that is being developed for hypertension. The renin-angiotensin-aldosterone system is responsible for the regulation of blood pressure. | ||
| M22490 | Recombinant Human C1QTNF1 Protein (HEK293, C-6His) | Cytokines and Growth Factors |
| Complement C1q Tumor Necrosis Factor-Related Protein 1 | ||
| C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1QTNF1 is a novel adipokine, providing a significant framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. C1QTNF1 increases the production of aldosterone. | ||
| M27663 | Dexfadrostat | Others |
| (R)-Fadrozole; (R)-CGS 16949A free base; FAD286 | ||
| Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.. | ||
| M28169 | Osilodrostat phosphate | Mineralocorticoid Receptor |
| LCI699 phosphate | ||
| Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. | ||
| M28408 | Baxdrostat | Mineralocorticoid Receptor |
| CIN-107 | ||
| Baxdrostat is a aldosterone synthase inhibitor. | ||
| M49422 | Lorundrostat | Mineralocorticoid Receptor |
| Lorundrostat is an aldosterone synthase inhibitor and is used in the research related to hypertension. | ||
| M50380 | Acetyl-ACTH (7-24) (human, bovine, rat) | Androgen Receptor |
| Acetyl-ACTH (7-24) (human, bovine, rat) causes a marked decrease of ACTH-evoked corticosterone and aldosterone release. | ||
| M57251 | 18-Oxocortisol | Mineralocorticoid Receptor |
| 18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). | ||
| M58552 | Recombinant Human Adrenomedullin Protein (HEK293, N-hFc) | Cytokines and Growth Factors |
| rhADM | ||
| Adrenomedullin is a a hypotensive peptide and has 1 intramolecular disulfide bond. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. | ||
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