Baxdrostat is a aldosterone synthase inhibitor.
| Molecular Weight | 363.45 |
| Formula | C22H25N3O2 |
| CAS Number | 1428652-17-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Marie Fisk. N Engl J Med. Baxdrostat for Treatment-Resistant Hypertension
[2] Nicasia D'Allesandro, et al. N Engl J Med. Baxdrostat for Treatment-Resistant Hypertension
[3] Yujiro Kida. N Engl J Med. Baxdrostat for Treatment-Resistant Hypertension
| Related Mineralocorticoid Receptor Products |
|---|
| Lorundrostat
Lorundrostat is an aldosterone synthase inhibitor and is used in studies related to hypertension. |
| LY2623091
LY2623091 is a salicorticoid receptor (MR) antagonist that may be used in studies related to chronic kidney disease and hypertension. |
| Desoxycorticosterone pivalate
Desoxycorticosterone pivalate (DOCP) is a salt corticosteroid that may be used in studies related to primary hypoadrenocorticism (PH). |
| Ocedurenone
Ocedurenone is a novel nonsteroidal salicorticoid receptor (MR) antagonist that may be used in studies related to kidney disease. |
| Osilodrostat phosphate
Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
