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Recombinant Human C1QTNF1 Protein (Mammalian, C-6His)

Cat. No. M22490
Recombinant Human C1QTNF1 Protein (Mammalian, C-6His) Structure

Complement C1q Tumor Necrosis Factor-Related Protein 1

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 505  USD505 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

C1QTNF1 is a secreted protein,contains 1 C1q domain and 1 collagen-like domain. C1QTNF1 is a novel adipokine, providing a significant framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. C1QTNF1 increases the production of aldosterone. Recombinant Human Complement C1q and Tumor Necrosis Factor-Related Protein 1 is produced by Mammalian expression system and the target gene encoding Arg26-Pro281 is expressed with a 6His tag at the C-terminus.

Accession: Q9BXJ1

APMol Mass: 37 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dough Kim, et al. Genes Genomics. C1q and TNF related protein 1 regulates expression of inflammatory genes in vascular smooth muscle cells

[2] Leiming Wu, et al. Free Radic Biol Med. C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway

[3] Ying Yang, et al. Cell Physiol Biochem. Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

[4] Lin Lu, et al. Eur Heart J. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis

[5] H Li, et al. Lett Appl Microbiol. High-level expression, purification and characterization of active human C1q and tumour necrosis factor-related protein-1 in Escherichia coli

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Keywords: Recombinant Human C1QTNF1 Protein (Mammalian, C-6His), Complement C1q Tumor Necrosis Factor-Related Protein 1 supplier, Recombinant Proteins, inhibitors, activators

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