About 30 results found for searched term "ARP" (0.02 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1785 | 3-Aminobenzamide | PARP |
| PARP-IN-1; 3-ABA | ||
| 3-Aminobenzamide (PARP-IN-1) is a novel poly(ADP-ribose) polymerase (PARP) inhibitor, and it inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way. | ||
| M2243 | Aniracetam | AChR/AChE |
| Draganon, Sarpul | ||
| Aniracetam is a compound that promotes intellectual development and neuroprotection. | ||
| M2495 | Carprofen | COX |
| Carprofen inhibits canine COX2 with IC50 of 0.03 mM. | ||
| M2944 | Pilocarpine hydrochloride | Animal Modeling |
| Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3913 | Sophocarpine monohydrate | Autophagy |
| Sophocarpine monohydrate is a HERG K+ channel blocker with IC50 of 100-300 μM and Na+ channel inward current inhibitor. Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. | ||
| M3966 | Oxysophocarpine | Others |
| OSC | ||
| Oxysophocarpine (OSC), a quinolizidine alkaloid extracted from leguminous plants of the genus Robinia, is traditionally used for various diseases including neuronal disorders. | ||
| M4284 | Harpagoside | COX |
| Harpagoside was separated from Harpagophytum procumbens (Hp). Harpagoside inhibited COX-1 and COX-2 activity and NO production. | ||
| M4285 | Harpgide | Parasite |
| Harpgide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. | ||
| M4302 | Solasodine | p53 |
| Purapuridine; Solancarpidine; Solasodin | ||
| Solasodine (Purapuridine) is a steroid alkaloid found in solanaceae plants. Solasodine has neuroprotective, antifungal, antihypertensive, anticancer, antiatherosclerotic, antiandrogen and anti-inflammatory activities. | ||
| M4437 | Rutaecarpine | COX |
| Rutecarpine | ||
| Rutaecarpine is a delayed rectifier K+ channel blocker, inhibits platelet aggregation. | ||
| M4493 | Casticin (Vitexicarpin) | STAT |
| Casticin | ||
| Casticin (Vitexicarpin) is a methoxyl flavonoid compound obtained from fructus vitae and has anti-mitotic and anti-inflammatory activities. Casticin inhibits the activation of STAT3. | ||
| M4672 | 8-O-Acetylharpagide | Antibiotic |
| 8-O-acetylharpagide is a kind of iridoid compound isolated from Ajuga reptans and has anti-tumor, antiviral, antibacterial and anti-inflammatory activities. 8-O-acetylharpagide also has bioactivity on isolated smooth muscle of guinea pig. | ||
| M4760 | Pterostilbene | Autophagy |
| Pterocarpus marsupium | ||
| Pterostilbene is an antioxidant that primarily exists in blueberries, grapevines and heartwood of red sandalwood. | ||
| M5951 | Sarpogrelate HCl | 5-HT Receptor |
| MCI-9042 | ||
| Sarpogrelate (MCI-9042) hydrochloride, a selective 5-HT2 antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. | ||
| M6463 | ARP 101 | Others |
| ARP 101 is a inhibitor of MMP-2. | ||
| M8019 | Pilocarpine nitrate salt | Animal Modeling |
| Pilocarpine nitrate salt is a non-selective muscarinic acetylcholine receptor (AChR) agonist used to construct experimental models of epilepsy. In addition, Pilocarpine constricts the pupil, enhances depth of field, and improves near and intermediate vision, which can be used in studies related to presbyopia. | ||
| M13570 | Sophocarpine | Autophagy |
| Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. | ||
| M13712 | PARP1-IN-5 dihydrochloride | PARP |
| PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer. | ||
| M13957 | Carperitide acetate | Endothelin Receptor |
| Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate | ||
| Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. | ||
| M16007 | 9α-Hydroxysophocarpine | Alkaloids |
| 9α-Hydroxysophocarpine | ||
| M16049 | Dihydroevocarpine | Alkaloids |
| Dihydroevocarpine | ||
| M16365 | 13-Oxopodocarp-8(14)-en-18-oic acid | Diterpenoids |
| 13-Oxopodocarp-8(14)-en-18-oic acid | ||
| M16480 | Carpalasionin | Diterpenoids |
| Carpalasionin | ||
| M16622 | 5-Dehydroxyparatocarpin K | Flavonoids |
| 5-Dehydroxyparatocarpin K | ||
| M16666 | Podocarpusflavone A | Flavonoids |
| Podocarpusflavone A | ||
| M16844 | 6-Epi-8-O-acetylharpagide | Iridoids |
| 6-Epi-8-O-acetylharpagide | ||
| M16934 | (+)-Conocarpan | Lignans |
| (+)-Conocarpan | ||
| M17180 | 6a-Hydroxymedicarpin | Phenols |
| 6a-Hydroxymedicarpin | ||
| M17218 | Pterocarpadiol A | Phenols |
| Pterocarpadiol A | ||
| M17222 | Homopterocarpin | Phenols |
| Homopterocarpin | ||
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