Matrine is a bioactive ingredient obtained from foxtail-like matrine herbs and seeds and is often used in oral cancer and chronic bronchial asthma studies. Sophorine is absorbed mainly by passive diffusion, and the vector mediated mechanism is also involved in sophorine transport. Sophorine can reduce the expression of TLR4 and inhibit the synthesis of pro-inflammatory cytokines in steatosis hepatocytes. NF-κB, JNK and ERK signaling pathways are important downstream pathways. Sophorine alleviates liver fibrosis mainly by inhibiting TLR4 pathway. Sophorine may be a potential chemotherapeutic agent for chronic liver disease. Sophorine has potential anti - fibrosis effect. The mechanism may be that the NF-κB signaling pathway regulates the balance between proinflammatory cytokines expression and collagen content and the expression of MMPs.
| Molecular Weight | 246.35 |
| Formula | C15H22N2O |
| CAS Number | 145572-44-7 |
| Form | Solid |
| Solubility (25°C) | DMSO >10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Autophagy Products |
|---|
| Sofalcone
Sofalcone is a gastric antiulcer agent, it is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
| P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. |
| FDW028
FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. |
| Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
| Microcolin H
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
