Free shipping on all orders over $ 500

INO-1001

Cat. No. M13709

All AbMole products are for research use only, cannot be used for human consumption.

INO-1001 Structure
Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 165  USD165 In stock
25mg USD 330  USD330 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death. INO-1001 has anti-tumor effects.

Chemical Information
Molecular Weight 439.53
Formula C23H25N3O4S
CAS Number 501364-82-5
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Agop Y Bedikian, et al. Cancer Invest. A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma

[2] David A Morrow, et al. J Thromb Thrombolysis. A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary perc䲧璵Ỵ璶㧀璴羹癦璤桸ܷŞܷ �癨嶁癤Ѐ

[3] Kathryn A Mason, et al. Invest New Drugs. INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase, enhances tumor response to doxorubicin

[4] Balzs Hauser, et al. Shock. The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion

[5] Gbor Szab, et al. Shock. INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation

Related PARP Products
2-Methylquinazolin-4-ol

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with IC50 of 0.20 mM.

DPQ 

DPQ is a potent PARP-1 inhibitor.

OUL232 

OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15.

AZ3391 

AZ3391 is a potent inhibitor of PARP.

PARP1-IN-5 

PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: INO-1001 supplier, PARP, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.