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 About 11 results found for searched term "PARP" (0.043 seconds)

Cat.No.  Name Target
M13712 PARP1-IN-5 dihydrochloride PARP
PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
M29181 PARP14 inhibitor H10  PARP
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis.
M29548 PROTAC PARP1 degrader  PROTAC
PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
M41360 PARP-1/2-IN-2 PARP
PARP-1/2-IN-2-IN-1 is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively).
M41572 PARP-1-IN-3 PARP
PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively.
M41575 PARP1-IN-14 PARP
PARP1-IN-14 is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM.
M41577 PARP-1-IN-13 PARP
PARP-1-IN-13 is a PARP-1 inhibitor (IC50: 26 nM).
M41578 PARP-1-IN-4 PARP
PARP-1-IN-4 is a PARP-1 inhibitor.
M42940 ARTD3/PARP3-IN-1 Others
ARTD3/PARP3-IN-1 is an unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3.
VEGFR/PARP-IN-1 is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively).
PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

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