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Cat. No. M43519
VEGFR/PARP-IN-1 Structure
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Biological Activity

VEGFR/PARP-IN-1 is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively).

Chemical Information
Molecular Weight 517.58
Formula C29H27N9O
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Peace Mabeta et al. Int J Mol Sci. The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy

[2] L Abdulazeem et al. Arch Razi Inst. An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing

[3] Michael Simons et al. Nat Rev Mol Cell Biol. Mechanisms and regulation of endothelial VEGF receptor signalling

[4] Wei Li et al. Discov Med. Targeting VEGF/VEGFR in the treatment of psoriasis

[5] Rosana D Meyer et al. Ann N Y Acad Sci. Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems?

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Abmole Inhibitor Catalog

Keywords: VEGFR/PARP-IN-1 supplier, PARP, inhibitors, activators

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