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PARP Poly-ADP-ribose polymerase

Inhibitors

Cat.No.  Name Information
M1732 BMN673 (Talazoparib) Talazoparib (BMN-673) 是一种高效的,具有口服活性的 PARP 1/2 抑制剂。Talazoparib 抑制 PARP1 和 PARP2 酶活性的 Ki 值分别为 1.2 nM 和 0.87 nM。Talazoparib 具有抗肿瘤活性。
M3932 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
M4931 Rucaparib Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
M1664 AZD2281 (Olaparib) AZD 2281 (Olaparib, KU-0059436) is a potent PARP (poly ADP-ribose polymerase) inhibitorwith IC50 of 5 and 1 nM for PARP-1and PARP-2 respectively.
M2215 Niraparib (MK-4827) Niraparib (MK-4827) is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.
M13715 Veliparib dihydrochloride Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.
M13714 Talazoparib tosylate Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1.
M13713 RK-287107 RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth.
M13712 PARP1-IN-5 dihydrochloride PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
M13711 Niraparib hydrochloride Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively.
M13710 iRucaparib-AP6 iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1.
M13709 INO-1001 INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor.
M13431 KSQ-4279 KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.
M13392 GeA-69 GeA-69 is a cell-penetrating selective allosteric inhibitor targeting Macrodomain 2 (MD2) with a Kd of 2.1 µM.
M13391 RBN012759 RBN012759 is a potent, selective and orally active PARP14 inhibitor with IC50 values of <3 nM and 5 nM against the human and mouse catalytic domains, respectively. AIDS in the anti-tumor immune response.
M11443 KSQ-4279 Usp1-in-1 (Formula I), an allosteric INHIBITOR of USP1, has been used IN cancer studies alone or IN combination with PARP inhibition.
M10445 Fluzoparib (SHR3162) Fluzoparib (SHR3162) is an effective oral active PARP1 inhibitor (IC50=1.46±0.72 nM) with superior antitumor activity. Fluzoparib selectively inhibited the proliferation of homologous recombination repair (HR) deficient cells and sensitized HR deficient cells to cytotoxic drugs. Fluzoparib has good pharmacokinetic properties in vivo and can be used in cancer research.
M10298 AZD5305 AZD5305 is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor.
M9864 BRCA1-IN-2 BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM.
M9602 RBN-2397 RBN-2397 is a potent, orally active NAD+ competitive PARP7 inhibitor with an IC50 value of less than 3 nM. Rnb-2397 can directly inhibit cell proliferation and restore type I interferon signaling by inhibiting PARP7 in tumor cells to stimulate innate or adaptive antitumor immune responses
M9525 Pamiparib Pamiparib (BGB-290) is an orally active, potent, highly selective inhibitor of PARP1 and PARP2 with IC50 values of 0.9 nM and 0.5 nM, respectively.
M9253 BGP-15 2HCl BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor with an IC50 and a Ki of 120 μM and 57 μM, respectively.
M9139 Benzamide Benzamide is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3.3 μM.
M9138 Picolinamide Picolinamide is a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
M8926 Niraparib (MK-4827) tosylate Niraparib (MK-4827) tosylate is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.



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