RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth.
International Journal of Molecular Sciences. 2023 Apr 4.
Wnt Signaling Ianhibitors and Their Promising Role in Tumor Treatment
RK-287107 purchased from AbMole
Int J Mol Sci. 2023 Apr 4;24(7):6733.
Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
RK-287107 purchased from AbMole
| Molecular Weight | 416.46 |
| CAS Number | 2171386-10-8 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 2-8°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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