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PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.
Molecular Weight | 768.83 |
Formula | C43H41FN8O5 |
CAS Number | 2687273-52-3 |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Dea Slade. Genes Dev. PARP and PARG inhibitors in cancer treatment
[3] Yijie Wang, et al. DNA Repair (Amst). PARP-1 and its associated nucleases in DNA damage response
[5] Junko Murai, et al. Cancer Res. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
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