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PARP/EZH2-IN-1

Cat. No. M45107

All AbMole products are for research use only, cannot be used for human consumption.

PARP/EZH2-IN-1 Structure

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Quality Control & Documentation
Biological Activity

PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

Chemical Information
Molecular Weight 768.83
Formula C43H41FN8O5
CAS Number 2687273-52-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ashlesha Kadam, et al. Biochim Biophys Acta Gen Subj. Role of PARP-1 in mitochondrial homeostasis

[2] Dea Slade. Genes Dev. PARP and PARG inhibitors in cancer treatment

[3] Yijie Wang, et al. DNA Repair (Amst). PARP-1 and its associated nucleases in DNA damage response

[4] Xuan Jiang, et al. J Cell Mol Med. PARP inhibitors in ovarian cancer: Sensitivity prediction and resistance mechanisms

[5] Junko Murai, et al. Cancer Res. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

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  Catalog
Abmole Inhibitor Catalog




Keywords: PARP/EZH2-IN-1 supplier, PARP, inhibitors, activators

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