About 30 results found for searched term "ALS" (0.041 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2429 | Balsalazide disodium | Sirtuin |
| Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis. | ||
| M3507 | Valsartan | Angiotensin Receptor |
| CGP 48933 | ||
| Valsartan is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to 116 μM. | ||
| M1606 | Aluminum stearate | Adjuvants |
| ALS; Tristearic acid aluminum salt | ||
| Aluminum stearate is a saline form of stearic acid used as a thickener and emulsifier, and to regulate the stability and suspension of a cosmetic formulation, used as adjuvant. | ||
| M5444 | Balsalazide | IL Receptor/Related |
| Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. | ||
| M5731 | LCZ696 | Angiotensin Receptor |
| Sacubitril/Valsartan；Entresto | ||
| LCZ696, consisting of Valsartan and Sacubitril in a 1:1 molar ratio, is a first-in-class dual-action angiotensin receptor-neprilysin inhibitor (ARNi,angiotensin receptor-neprilysin inhibitor) for the study of hypertension and heart failure. | ||
| M6267 | Valspodar | P-glycoprotein |
| PSC 833 | ||
| Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator. | ||
| M7245 | Salsolinol-1-carboxylic acid | Others |
| Salsolinol-1-carboxylic acid is a endogenous amino acid. | ||
| M7352 | Talsupram hydrochloride | Others |
| Talsupram hydrochloride is a selective inhibitor of noradrenalin transporters. | ||
| M8326 | Salsolinol hydrobromide | Others |
| Salsolinol is the condensation product of acetaldehyde and dopamine. | ||
| M8799 | Talsaclidine | Others |
| Talsaclidine is a M1 selective muscarinic receptor agonist. | ||
| M9346 | Pralsetinib | RET |
| BLU-667 | ||
| Pralsetinib (BLU-667) is a next generation highly potent, selective RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. | ||
| M11406 | Berotralstat | Serine/Threonine Protease |
| Berotralstat (BCX7353) was a second generation plasma kallikrein inhibitor with low toxicity and high specificity, and was used for the diagnosis of hereditary angioedema (HAE). Berotralstat works by blocking the enzyme activity of plasma Kallikrein that releases bradykinin, a major biological peptide that promotes swelling and pain associated with HAE attacks. | ||
| M13594 | Alsterpaullone | CDK |
| 9-Nitropaullone; NSC 705701 | ||
| Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. | ||
| M14532 | Avoralstat | Serine/Threonine Protease |
| BCX4161 | ||
| Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research. | ||
| M16031 | Tetrahydroalstonine | Adrenergic Receptor |
| Tetrahydroalstonine is a selective alpha 2-adrenoceptor antagonist. | ||
| M16513 | Przewalskin | Diterpenoids |
| Przewalskin | ||
| M17781 | Alstonic acid A | Triterpenoids |
| Alstonic acid A | ||
| M17783 | Walsuralactam A | Triterpenoids |
| Walsuralactam A | ||
| M18403 | Przewalskinic acid A | Others |
| Przewalskinic acid A | ||
| M21530 | Sebetralstat | Serine/Threonine Protease |
| KVD900 | ||
| Sebetralstat is an orally active plasma kininase (KLKB1) inhibitor for studies related to hereditary angioedema (HAE). | ||
| M24953 | Balstilimab | PD-1/PD-L1 |
| AGEN2034 | ||
| Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1. | ||
| M24994 | Palsucibep pegol | Others |
| Palsucibep pegol is a engineered human lipocalin-2 binding protein. Palsucibep pegol binds to hepcidin. | ||
| M25051 | Alsevalimab | Others |
| Alsevalimab is a human monoclonal antibody against B7-H4. | ||
| M28451 | ALS-8112 | RSV |
| ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM. | ||
| M28905 | Berotralstat dihydrochloride | Serine/Threonine Protease |
| BCX7353 dihydrochloride | ||
| Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. | ||
| M29315 | Feniralstat | Serine/Threonine Protease |
| Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM). | ||
| M29879 | ALS-I | Others |
| ALS-I, an acid-Liable surfactant, is adopted for in-solution enzymatic digestions, can help to solubilize hydrophobic proteins. ALS-I is significantly enhanced peptide recovery for mass spectrometry (MS) mapping in the study of the proteomes of regenerating rat retina and mouse brain. | ||
| M30417 | Alstonine | Parasite |
| Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties. | ||
| M39167 | Uralsaponin D | Phosphatase |
| Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA2) with an IC50 value of 32.2 μM. | ||
| M40336 | Uralsaponin C | Others |
| Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch. | ||
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