LCZ696, consisting of Valsartan and Sacubitril in a 1:1 molar ratio, is a first-in-class dual-action angiotensin receptor-neprilysin inhibitor (ARNi,angiotensin receptor-neprilysin inhibitor) for the study of hypertension and heart failure.
BMC Cardiovasc Disord. 2024 Feb 14;24(1):106.
Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway
LCZ696 purchased from AbMole
Molecular Weight | 915.98 |
Formula | C24H29N5O3.C24H29NO5.5/2H2O.3Na |
CAS Number | 936623-90-4 |
Solubility (25°C) | Water 50 mg/mL DMSO 50 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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