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LCZ696

Cat. No. M5731
LCZ696 Structure
Synonym:

Sacubitril/Valsartan;Entresto

Size Price Availability Quantity
5mg USD 48  USD48 In stock
10mg USD 72  USD72 In stock
25mg USD 96  USD96 In stock
50mg USD 144  USD144 In stock
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Quality Control & Documentation
Biological Activity

LCZ696, consisting of Valsartan and Sacubitril in a 1:1 molar ratio, is a first-in-class dual-action angiotensin receptor-neprilysin inhibitor (ARNi,angiotensin receptor-neprilysin inhibitor) for the study of hypertension and heart failure.

Product Citations
Chemical Information
Molecular Weight 915.98
Formula C24H29N5O3.C24H29NO5.5/2H2O.3Na
CAS Number 936623-90-4
Solubility (25°C) Water 50 mg/mL
DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Simpson J, et al. J Am Coll Cardiol. Comparing LCZ696 with enalapril according to baseline risk using the MAGGIC and EMPHASIS-HF risk scores: an analysis of mortality and morbidity in PARADIGM-HF.

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  Catalog
Abmole Inhibitor Catalog




Keywords: LCZ696, Sacubitril/Valsartan;Entresto supplier, Angiotensin Receptor, inhibitors, activators


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