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Valsartan (Diovan) is an angiotensin II receptor antagonist with IC50 of ranging from 39.5 to116 uM. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the Value trial, the angiotensin II receptor blocker valsartan produced a statistically significant 19% (p=0.02) relative increase in the prespecified secondary end point of myocardial infarction (fatal and non-fatal) compared with amlodipine. The CHARM-alternative trial showed a significant +52% (p=0.025) increase in myocardial infarction with candesartan (versus placebo) despite a reduction in blood pressure.
BMC Cardiovasc Disord. 2024 Feb 14;24(1):106.
Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway
Valsartan purchased from AbMole
| Molecular Weight | 435.52 |
| Formula | C24H29N5O3 |
| CAS Number | 137862-53-4 |
| Solubility (25°C) | DMSO 77 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Kieran F Docherty, et al. Sacubitril/Valsartan: Neprilysin Inhibition 5 Years After PARADIGM-HF
[4] Renato De Vecchis, et al. Antihypertensive effect of sacubitril/valsartan: a meta-analysis
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