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Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension. Azilsartan potently inhibited vascular cell proliferation in the absence of exogenously supplemented angiotensin II. Azilsartan increased tissue glucose uptake, especially in skeletal muscle and adipose tissue. In cultured 3T3-L1 preadipocytes, azilsartan enhanced adipogenesis and exerted greater effects than valsartan on expression of genes encoding peroxisome proliferator-activated receptor-α (PPARα), PPARδ, leptin, adipsin, and adiponectin. In adipose tissue, Azilsartan (TAK-536) reduced TNF-alpha expression but increased the expression of adiponectin, PPARgamma, C/EBalpha, and aP2. In addition, azilsartan downregulated 11β-hydroxysteroid dehydrogenase type 1 expression. Azilsartan is currently in a phase IV clinical trial in the treatment of hypertension.
Tampere University. 2021.
Novel Targeted Therapies and Prognostic Markers for T Cell Acute Lymphoblastic Leukemia
Azilsartan purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | male Wister rats, aged 6–8 weeks |
| Formulation | Na-CMC |
| Dosages | 3.5 mg/kg, 7 mg/kg |
| Administration | p.o. |
| Molecular Weight | 456.45 |
| Formula | C25H20N4O5 |
| CAS Number | 147403-03-0 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Angiotensin Receptor Products |
|---|
| Azilsartan medoxomil
Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. |
| PD 123319 ditrifluoroacetate
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. |
| Candesartan
Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM. |
| Tasosartan
Tasosartan is a selective, potent, orally active and long-acting nonpeptide Angiotensin II type 1 (AT1) receptor antagonist. |
| PD 123319
PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. |
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