About 30 results found for searched term "AGR" (0.039 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1721 | AZD4547 | FGFR |
| Fexagratinib; ABSK091 | ||
| AZD4547 is a potent, selective and orally active pan-FGFR inhibitor with IC50s of 0.2. 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. | ||
| M2286 | Sildenafil citrate | PDE |
| Viagra, Revatio | ||
| Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). | ||
| M2395 | Anagrelide hydrochloride | PDE |
| BL-4162A | ||
| Anagrelide HCl is a primary thrombocytopenia compound. It has anti-cyclic adenylate phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting megakaryocytes from maturing into platelets. | ||
| M3069 | Ticagrelor | P2 Receptor |
| AR-C 126532XX; AZD6140 | ||
| Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM respectively. | ||
| M3335 | Ozagrel | Factor Xa |
| OKY-046 | ||
| Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM. | ||
| M4674 | Agrimol-B | Sirtuin |
| Agrimol B is a polyphenol derivative isolated from Sepulchrum, which can inhibit fat formation, induce translocation and expression of SIRT1, and reduce the expression of PPARγ. | ||
| M5846 | Ozagrel HCl | Prostaglandin Receptor |
| OKY-046 HCl | ||
| Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. | ||
| M5847 | Ozagrel sodium | Factor Xa |
| OKY-046 sodium | ||
| Ozagrel(OKY-046) sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. | ||
| M5959 | Sildenafil | PDE |
| Revatio, UK-92480, Viagra | ||
| Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. | ||
| M7095 | Ozagrel hydrochloride | Others |
| Ozagrel hydrochloride is a selective thromboxane A 2 synthetase inhibitor. | ||
| M9428 | MRTX849 (Adagrasib) | Ras |
| Adagrasib; MRTX-849 | ||
| MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. | ||
| M10214 | Agouti-related Protein (AGRP) (25-82), human | Peptides |
| Agouti-related protein (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. | ||
| M14042 | Vicagrel | Others |
| Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis, the substrate of carboxylesterase 2 (CES2). | ||
| M16120 | Agrocybenine | Alkaloids |
| Agrocybenine | ||
| M16259 | Agrimonolide 6-O-glucoside | Coumarins |
| Agrimonolide 6-O-glucoside | ||
| M17828 | Aphagranin A | Triterpenoids |
| Aphagranin A | ||
| M18559 | Tellimagrandin II | Others |
| Tellimagrandin II | ||
| M24625 | Bimagrumab | TGF-beta/Smad |
| BYM338 | ||
| Bimagrumab (BYM338) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness. | ||
| M24751 | Domagrozumab | Others |
| PF-06252616 | ||
| Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD). | ||
| M24892 | Tagraxofusp | IL Receptor/Related |
| SL-401 | ||
| Tagraxofusp (SL-401) is a potent IL-3 receptor inhibitor to inhibits plasmacytoid dendritic cells (pDCs) growth in multiple myeloma (MM) bone marrow (BM) microenvironment. Tagraxofusp has synergistic effect with Bortezomib and Pomalidomide to suppress multiple myeloma (MM). | ||
| M24969 | Magrolimab | Others |
| Hu5F9-G4 | ||
| Magrolimab (Hu5F9-G4) is a first-in-class humanized anti-CD47 IgG4 antibody with an anti-tumor activity. | ||
| M25549 | AS 1411 | Others |
| AGRO-100 | ||
| AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. AS1411 has anti-tumor activity. | ||
| M27703 | Dagrocorat | GCR |
| PF-00251802 | ||
| Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis. | ||
| M27704 | Fosdagrocorat | GCR |
| PF-04171327 | ||
| Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist. | ||
| M27705 | Dagrocorat hydrochloride | GCR |
| PF-00251802 hydrochloride | ||
| Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis. | ||
| M28370 | Cagrilintide acetate | CGRP Receptor |
| Cagrilintide acetate is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity. | ||
| M29301 | Agrimonolide | Others |
| Agrimonolide (compound 9) is a natural product is isolated from agrimonia pilosa. | ||
| M30483 | Anagrelide | PDE |
| Anagrelide, an inhibitor of phosphodiesterase type III (PDEIII) (IC50=36 nM), inhibits platelet production. Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide plays in the antithrombopoietic action. The platelet-lowering agent. | ||
| M30648 | Anagrelide hydrochloride monohydrate | PDE |
| Anagrelide hydrochloride monohydrate is a imidazoquinazoline agent. Anagrelide hydrochloride monohydrate decreases the level of platelets in blood, prevents blood clots formation. Anagrelide hydrochloride monohydrate can be used for research of essential thrombocythaemia (ET) and thrombocythaemia associated with polycythaemia vera (PV). | ||
| M40337 | Fragransin A2 | Others |
| Fragransin A2 is a lignan that can be isolated from the stems of Knema furfuracea (Myristicaceae). Fragransin A2 shows anticancer activity. | ||
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