Free shipping on all orders over $ 500

AS 1411

Cat. No. M25549
AS 1411 Structure
Synonym:

AGRO-100

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

AS1411 is a quadruplex-forming oligonucleotide aptamer that targets nucleolin. AS1411 has anti-tumor activity.

Chemical Information
Molecular Weight 8272.31
CAS Number 301636-59-9
Form Solid
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shipeng He, et al. Angew Chem Int Ed Engl. Aptamer-PROTAC Conjugates (APCs) for Tumor-Specific Targeting in Breast Cancer

[2] Benedetta Ferrara, et al. Nanotechnology. Cell surface nucleolin as active bait for nanomedicine in cancer therapy: a promising option

[3] Rezvan Yazdian-Robati, et al. Int J Biol Macromol. Therapeutic applications of AS1411 aptamer, an update review

[4] Tiago Santos, et al. Eur J Pharm Biopharm. RNA G-quadruplex as supramolecular carrier for cancer-selective delivery

[5] Fabien Mongelard, et al. Curr Opin Mol Ther. AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia

Related Products
Olezarsen

Olezarsen, an N-acetylgalactosamine (GalNAc)-suffixed antisense oligonucleotide (ASO) targeting hepatic APOC3 mRNA, inhibits the production of apolipoprotein C-III (apoC-III) and can be used in studies related to familial celiac sprue syndrome (FCS).

Lumasiran

Lumasiran is a siRNA compound that reduces hepatic oxalate production by targeting ethanoic acid oxidase.

Givosiran

Givosiran is a small interfering RNA that targets hepatic aminofibrillar synthase 1 (ALAS1) messenger RNA, down-regulates ALAS1 mRNA, and prevents the accumulation of neurotoxic α-aminofibrillar acids and porphyrins, which can be used in porphyria-related studies.

Viltolarsen

Viltolarsen is a phosphorodiamidomorpholine antisense oligonucleotide that targets splicing of exon 53 of the myotonic dystrophy protein gene and can be used in the study of Duchenne muscular dystrophy (DMD).

Golodirsen

Golodirsen is a phosphodiesteric morpholino oligomer (PMO) that specifically targets exon 53 of the pre-protein mRNA of myotonic dystrophy protein culture proteins, and can be used in studies related to Duchenne muscular dystrophy (DMD).

  Catalog
Abmole Inhibitor Catalog




Keywords: AS 1411, AGRO-100 supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.