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Anagrelide hydrochloride

Cat. No. M2395
Anagrelide hydrochloride Structure
Synonym:

BL-4162A

Size Price Availability Quantity
50mg USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Anagrelide HCl is a primary thrombocytopenia compound. It has anti-cyclic adenylate phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting megakaryocytes from maturing into platelets.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 292.55
Formula C10H7Cl2N3O.HCl
CAS Number 58579-51-4
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Mirjana Gotic, et al. Cardiovascular Safety of Anagrelide Hydrochloride versus Hydroxyurea in Essential Thrombocythaemia

[2] No authors listed. Anagrelide

[3] No authors listed. Anagrelide

[4] Marina Kremyanskaya, et al. Anagrelide hydrochloride and ruxolitinib for treatment of polycythemia vera

[5] Claire N Harrison, et al. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia

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