About 12 results found for searched term "AG 18" (1.251 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2021 | AG 18 | EGFR/HER2 |
| RG-50810；Tyrphostin 23；tyrA23；Tyrphostin A23 | ||
| AG-18 (Tyrphostin A23, tyrA23) inhibits EGFR with an IC50 of 35 μM. TyrA23 is also an inhibitor of CME and inhibits transferrin receptor internalization. | ||
| M2331 | PP2 | Src-bcr-Abl |
| AG 1879; AGL1879 | ||
| PP2 (AGL 1879) is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2. | ||
| M2953 | PP1 | Src-bcr-Abl |
| AGL 1872, EI 275 | ||
| PP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM. | ||
| M14572 | Jagged-1 (188-204) TFA | Notch |
| Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells. | ||
| M21052 | SAGE-718 | GluR |
| Dalzanemdor | ||
| Dalzanemdor (SAGE-718) is an oral N-methyl-d-aspartate receptor (NMDAR) Positive Allosteric Modulator (PAM) being developed for cognitive impairment in Huntington’s disease. | ||
| M21776 | AGN 195183 | Others |
| AGN 195183 | ||
| M24820 | Valanafusp alfa | Insulin Receptor |
| AGT-181; HIRMAb-IDUA | ||
| Valanafusp alfa (AGT-181) is a brain penetrating recombinant fusion protein of a chimeric monoclonal antibody against the human insulin receptor (HIR) and human iduronidase (IDUA). Valanafusp alfa can be used for the research of Mucopolysaccharidosis type I (MPS I) . | ||
| M24952 | Zalifrelimab | Others |
| AGEN1884 | ||
| Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling. | ||
| M24988 | Ragifilimab | TNF Receptor |
| INCAGN-1876 | ||
| Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab can be used for advanced or metastatic solid tumors research. | ||
| M25119 | Botensilimab | Others |
| AGEN 1181 | ||
| Botensilimab (AGEN 1181), a humanized anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer. | ||
| M27979 | (Z)-Tyrphostin A51 | EGFR/HER2 |
| (Z)-AG-183 | ||
| (Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation. | ||
| M52408 | Jagged-1 (188-204) | Notch |
| Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. | ||
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