About 18 results found for searched term "83-12-5" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3348 | Phenindione | Others |
| Rectadione, phenylindandione | ||
| Phenindione is an anticoagulant which functions as a Vitamin K antagonist. | ||
| M6606 | Cinalukast | Others |
| Cinalukast is a potent, selective CysLT 1 (LTD 4) antagonist; orally active. | ||
| M24830 | Lacnotuzumab | CSF-1R (c-Fms) |
| MCS110; Anti-Human B7-H3 | ||
| Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis. | ||
| M39880 | 1-Hydroxymethyl-β-carboline glucoside | Others |
| 1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides. | ||
| M5037 | A 83-01 | TGF-β Receptor |
| A83-01; A-83-01 | ||
| A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended | ||
| M8634 | LUF5834 | Others |
| LUF5834 is a potent A2A and A2B adenosine receptor partial agonist with an EC50 value of 12 nM and 45-fold selectivity over the adenosine A3 receptor. | ||
| M10258 | SR-4835 | CDK |
| SR4835 | ||
| SR-4835 is a highly selective, dual inhibitor of CDK12 with IC50 values of 99 nM, Kd of 98 nM and CDK13 with Kd of 4.9 nM, respectively. | ||
| M14747 | NSC668394 | Others |
| NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 μM. | ||
| M24812 | Losatuxizumab | EGFR/HER2 |
| ABT-806 | ||
| Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody. Losatuxizumab binds to EGFR with EC50s of 0.96 nM for EGFR wild-type, 0.09 nM for EGFRC271A,C283A, 0.12 nM for EGFRvIII, 0.66 nM for EGFR1-501. Losatuxizumab can be used for research of EGFR-expressing cancers. | ||
| M28062 | PF-4950834 | ROCK |
| PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration. | ||
| M28481 | KDM2/7-IN-1 | Histone demethylase |
| KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro. | ||
| M29117 | Laninamivir | Anti-infection |
| R 125489 | ||
| Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively. | ||
| M29432 | WS-383 free base | E1/E2/E3 Enzyme |
| WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | ||
| M29433 | WS-383 | E1/E2/E3 Enzyme |
| WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | ||
| M30527 | NCGC00029283 | DNA/RNA Synthesis |
| NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. | ||
| M58133 | BAY-9835 | Others |
| BAY9835 | ||
| BAY-9835 is a potent and orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 is very selective against a range of off-targets and metalloproteases. | ||
| M54721 | A 83-01 sodium | TGF-beta/Smad |
| A 83-01 sodium is a potent inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7, inhibiting ALK5, ALK4, and ALK7-induced transcription with IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively. | ||
| M55310 | BI 1291583 | Dipeptidyl Peptidase |
| BI1291583 | ||
| BI 1291583 is a novel selective inhibitor of cathepsin C (CatC; DPP1). BI 1291583 bound human CatC (DPP1) in a covalent, reversible manner, selectively and fully inhibiting CatC enzymatic activity. | ||
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