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WS-383 

Cat. No. M29433

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WS-383  Structure

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Quality Control & Documentation
Biological Activity

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2.

Chemical Information
Molecular Weight 498.46
Formula C18H21Cl2N9S2
CAS Number 2247544-02-9
Form Solid
Solubility (25°C) DMSO 7.35 mg/mL (ultrasonic)
Storage 4°C, protect from light, dry, sealed
References

[1] Shuai Wang, et al. J Med Chem. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction

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  Catalog
Abmole Inhibitor Catalog




Keywords: WS-383  supplier, E1/E2/E3 Enzyme, inhibitors, activators

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