All AbMole products are for research use only, cannot be used for human consumption.
SR-4835 is a highly selective, dual inhibitor of CDK12 and CDK13 with IC50 values of 99 nM, Kd of 98 nM and Kd of 4.9 nM, respectively. SR-4835 has potent in vivo anti-TNBC activity and augments the anti-cancer activity of cisplatin, irinotecan, and olaparib, which are standard-of-care therapeutics for TNBC.
| Cell Experiment | |
|---|---|
| Cell lines | MDA-MB-231, MDA-MB-436, HS578T, MDA-MB-468, FHC |
| Preparation method | Clonogenic Assays. 500 cells per well are plated in six-well dishes in triplicate. After overnight incubation, SR-4835 is added to the medium for 72 hr, and cells are allowed to grow for 7 to 10 days, during which medium is changed every 2 to 3 days. |
| Concentrations | 10-90 nM, 0.4-10 μM |
| Incubation time | 4 h, 6 h, 72 h |
| Animal Experiment | |
|---|---|
| Animal models | Female SCID Beige mice bearing xenograft models BCM-4013 and BCM-3887 |
| Formulation | prepared in 10/90 DMSO/30% Hydroxypropyl-β-Cyclodextrin (hp-BCD) in water |
| Dosages | 20 mg/kg |
| Administration | PO 5 days per week |
| Molecular Weight | 499.36 |
| Formula | C21H20Cl2N10O |
| CAS Number | 2387704-62-1 |
| Solubility (25°C) | DMSO ≥ 6 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CDK Products |
|---|
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(E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor. |
| Abemaciclib metabolites M2
Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50 values of 1.2 and 1.3 nM, respectively. |
| CDK9-IN-1
CDK9-IN-1 is a novel, selective CDK9 inhibitor, with an IC50 of 39 nM for CDK9/CycT1, it can be used for the research of HIV infection. |
| XO44
XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. |
| ML 315
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. |
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