About 31 results found for searched term "59-50-7" (0.174 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M51149 | MOG (92–106), mouse, rat | Others |
| MOG (92–106), mouse, rat is a biological active peptide. | ||
| M1782 | NSC 74859 (S3I-201) | STAT |
| S3I-201 | ||
| NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M1822 | PD98059 | MEK |
| PD 98059; PD‐98059 | ||
| PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway. | ||
| M3131 | Wnt-C59 | Wnt/beta-catenin |
| C59 | ||
| Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM. | ||
| M3447 | PF-2545920 | PDE |
| Mardepodect; CAS# 898562-94-2 | ||
| PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. | ||
| M3773 | PSN 375963 | GPR/FFAR |
| PSN-375963 | ||
| PSN 375963 is an effective GPR119 agonist with EC50 of 8.4 and 7.9 μM for human and mice, respectively. PSN 375963 showed similar potency to endogenous oleoylethanolamide (OEA). | ||
| M5923 | Rebamipide | COX |
| OPC-12759 | ||
| Rebamipide (OPC12759) is a cholecystokinin-1 (CCK1) receptor inhibitor that inhibits [125I]BH-CCK-8S with an IC50 of 37.7 μM. Rebamipide is an orally effective gastroprotective agent. Rebamipide enhances the production of endogenous PGs (particularly intragastric PGE2) by inducing COX-2 expression, thereby protecting the gastric mucosa from injury. Rebamipide also has anti-proliferative activity against gastric cancer cells. | ||
| M6374 | A-804598 | P2 Receptor |
| A804598 | ||
| A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively. | ||
| M9425 | VU6015929 | Others |
| VU-6015929 | ||
| VU6015929 is a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50s of 4.67 nM and 7.39 nM, respectively. | ||
| M13405 | RIPK3-IN-1 | RIPK |
| RIPK3-IN-1 is a RIPK3 TYPE II DFG-out inhibitor with IC50 of 9.1 nM. RIPK3-IN-1 inhibited ABL, BRAF/V599E, MAP4K3 and SRC with IC50 values of 0.37, 0.15, 0.012 and 0.075 μM, respectively. | ||
| M13528 | AZD-5991 | Bcl-2 |
| AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. | ||
| M13841 | BAY-598 | Histone Methyltransferase |
| BAY-598 is selective small molecule inhibitor of SMYD2 with an IC50 of 27 nM. | ||
| M14201 | Mibefradil dihydrochloride | Calcium Channel |
| Ro 40-5967 dihydrochloride | ||
| Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively). | ||
| M14882 | Ibrutinib-biotin | BTK |
| Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK. | ||
| M20402 | Mardepodect (PF-2545920) | PDE |
| PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. | ||
| M21426 | BRD-K98645985 | HIV Protease |
| BRD-K98645985 is a mammalian SWI/SNF transcriptional repressor inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complex, prevents nucleosome localization, effectively reverses HIV-1 latency, and has no T-cell toxicity. | ||
| M25555 | BIIE-0246 hydrochloride | Neuropeptide Receptor |
| AR-H 053591 hydrochloride | ||
| BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy. | ||
| M28375 | RO-5963 | p53 |
| RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively. | ||
| M28381 | NSC 625987 | CDK |
| NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2. | ||
| M28741 | GS-626510 | Epigenetic Reader Domain |
| GS-626510 is a potent, and orally active BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively. | ||
| M28910 | BAY-7598 | MMP |
| BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively. | ||
| M28961 | TH1217 | Anti-infection |
| ZINC1775962367 | ||
| TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19. | ||
| M29120 | JNJ-61432059 | GluR |
| JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. | ||
| M29145 | PF-06445974 | PDE |
| PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC50 <1 nM. The IC50 values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study. | ||
| M29161 | Mardepodect hydrochloride | PDE |
| PF-2545920 hydrochloride | ||
| Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier. | ||
| M29749 | TP0597850 | MMP |
| TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min). | ||
| M29762 | MS432 | PROTAC |
| MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively. | ||
| M30503 | GI-530159 | Potassium Channel |
| GI-530159 is a selective opener of TREK1 and TREK2 potassium channels. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels, with an EC50 of 0.76 μM for TREK1. GI-530159 reduces rat dorsal root ganglion neuron excitability and shows potential analgesic effect. | ||
| M30839 | Mardepodect | PDE |
| PF-2545920 | ||
| Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier. | ||
| M39138 | 5-R-Rivaroxaban | Factor Xa |
| 5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM). | ||
| M41178 | HIV-1 inhibitor-59 | Anti-infection |
| HIV-1 inhibitor-59 is a HIV-1 inhibitor, with EC50s of 5.62-171 nM against the wild-type (WT) and mutant HIV-1 strains. | ||
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