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A-804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively). A-804598 is selective for P2X7 receptors (IC50 > 5-10 μM for a wide array of cell surface receptors and ion channels). A-804598 binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors).
| Molecular Weight | 315.37 |
| Formula | C19H17N5 |
| CAS Number | 1125758-85-1 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Brian Lord, et al. A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
| Related P2 Receptor Products |
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NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. |
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| NF110
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| PSB-12062
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| NF449 octasodium
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