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MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively.
| Molecular Weight | 1076.06 |
| Formula | C50H65F3IN7O6S |
| CAS Number | 2672512-44-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 260 mg/mL (ultrasonic) |
| Storage | -20°C, protect from light, sealed |
[1] Jing Liu, et al. J Am Chem Soc. Cancer Selective Target Degradation by Folate-Caged PROTACs
| Related PROTAC Products |
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| xStAx-VHLL TFA
xStAx-VHLL TFA, a PROTAC, sustains β-catenin degradation and manifested strong inhibition of Wnt signaling. xStAx-VHLL TFA promotes β-catenin ubiquitination. |
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