Certificate of Analysis
| Product Name: | MS432 |
| Catalog Number: | M29762 |
| CAS Number: | 2672512-44-4 |
Physical and Chemical Properties
| Formula: | C50H65F3IN7O6S |
| Molecular Weight: | 1076.06 |
| Form: | Solid |
| Solubility: | DMSO 260 mg/mL (ultrasonic) |
| Storage: | -20°C, protect from light, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |