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Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger). Zerumbone is a monocyclic sesquiterpene compound isolated from the rhizomes of Zingiber zerumbet Smith. Zerumbone potently inhibits the activation of Epstein-Barr virus with an IC50 of 0.14 mM. Zerumbone has anti-cancer, antioxidant, anti-inflammatory and anti-proliferative activity.
| Molecular Weight | 218.33 |
| Formula | C15H22O |
| CAS Number | 471-05-6 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | 4°C, protect from light |
[2] Hyun Jun Woo, et al. Zerumbone Inhibits Helicobacter pylori Urease Activity
[4] Hye-Won Cho, et al. Zerumbone Restores Gut Microbiota Composition in ETBF Colonized AOM/DSS Mice
[5] Sosmitha Girisa, et al. Potential of Zerumbone as an Anti-Cancer Agent
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