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UNC9995

Cat. No. M40719

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UNC9995 Structure

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Quality Control & Documentation
Biological Activity

UNC9995 is a novel β-arrestin 2-biased dopamine receptor Drd2 agonist that interferes with the assembly of inflammatory vesicles by enhancing the interaction of β-arrestin2 with NLRP3, thereby reducing IL-1β production.

Chemical Information
Molecular Weight 422.37
Formula C20H21Cl2N3OS
CAS Number 1354030-52-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yang Liu et al. J Neuroinflammation. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

[2] Jialei Zhu et al. Brain Behav Immun. Drd2 biased agonist prevents neurodegeneration against NLRP3 inflammasome in Parkinson's disease model via a β-arrestin2-biased mechanism

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Keywords: UNC9995 supplier, Dopamine Receptor, inhibitors, activators

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