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Spirapril

Cat. No. M30671

All AbMole products are for research use only, cannot be used for human consumption.

Spirapril Structure
Synonym:

SCH 33844

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Quality Control & Documentation
Biological Activity

Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure.

Chemical Information
Molecular Weight 466.61
Formula C22H30N2O5S2
CAS Number 83647-97-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ramón C Hermida, et al. Chronobiol Int. Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension

[2] A G Jardine, et al. J Cardiovasc Pharmacol. ACE inhibition in chronic renal failure and in the treatment of diabetic nephropathy: focus on spirapril

[3] K Hayduk, et al. J Cardiovasc Pharmacol. Efficacy and safety of spirapril in mild-to-moderate hypertension

[4] C Guitard, et al. Cardiovasc Drugs Ther. Comparison of efficacy of spirapril and enalapril in control of mild-to-moderate hypertension

[5] S Noble, et al. Drugs. Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension

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Keywords: Spirapril, SCH 33844 supplier, ACE, inhibitors, activators

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