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SKF 83822

Cat. No. M41813
SKF 83822 Structure
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Biological Activity

SKF 83822 is an atypical agonist of dopamine D1 receptor.

Chemical Information
Molecular Weight 343.85
Formula C20H22ClNO2
CAS Number 74115-08-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL (Need ultrasonic)
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Satoshi Fujita et al. Eur J Pharmacol. Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959

[2] Gerard J O'Sullivan et al. Neuropharmacology. Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling

[3] David Wirtshafter. Pharmacol Biochem Behav. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822

[4] Yasuyuki Makihara et al. Neurosci Lett. Differential involvement of cyclase- versus non-cyclase-coupled D1-like dopamine receptors in orofacial movement topography in mice: studies with SKF 83822

[5] Gerard J O'Sullivan et al. Eur J Pharmacol. SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography

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