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SKF-83566 hydrobromide 

Cat. No. M27764

All AbMole products are for research use only, cannot be used for human consumption.

SKF-83566 hydrobromide  Structure

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Biological Activity

SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta. SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation.

Chemical Information
Molecular Weight 413.15
Formula C17H19Br2NO
CAS Number 108179-91-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jason M Conley, et al. J Pharmacol Exp Ther. Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor

[2] C M Olarte-Sánchez, et al. Psychopharmacology (Berl). Effects of SKF-83566 and haloperidol on performance on progressive ratio schedules maintained by sucrose and corn oil reinforcement: quantitative analysis using a new model derived from the Mathematical Principles of Reinforcement (MPR)

[3] Rd Coppa-Hopman, et al. J Psychopharmacol. D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality

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Keywords: SKF-83566 hydrobromide  supplier, Dopamine Receptor, inhibitors, activators

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