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RM-018

Cat. No. M11427

All AbMole products are for research use only, cannot be used for human consumption.

RM-018  Structure
Synonym:

INDEX NAME NOT YET ASSIGNED

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Quality Control & Documentation
Biological Activity

RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C.

Chemical Information
Molecular Weight 985.22
Formula C56H72N8O8
CAS Number 2641993-55-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Noritaka Tanaka, et al. Cancer Discov. Clinical Acquired Resistance to KRAS G12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

[2] Leslie A McSweeney, et al. Cell Microbiol. Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit

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  Catalog
Abmole Inhibitor Catalog




Keywords: RM-018 , INDEX NAME NOT YET ASSIGNED supplier, Ras, inhibitors, activators

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