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RM-018

Cat. No. M11427
RM-018  Structure
Synonym:

INDEX NAME NOT YET ASSIGNED

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Quality Control
Biological Activity

RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 985.22
Formula C56H72N8O8
CAS Number 2641993-55-5
Purity
Solubility N/A
Storage at -20°C
References

[1] Noritaka Tanaka, et al. Cancer Discov. Clinical Acquired Resistance to KRAS G12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation

[2] Leslie A McSweeney, et al. Cell Microbiol. Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit

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  Catalog
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Keywords: RM-018 , INDEX NAME NOT YET ASSIGNED supplier, Ras, inhibitors

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