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Recombinant Mouse MFGE8 Protein (HEK293, C-6×His)

Cat. No. M40767

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse MFGE8 Protein (HEK293, C-6×His) Structure
Synonym:

MFGM

Size Price Availability Quantity
10ug USD 190  USD190 In stock
50ug USD 620  USD620 In stock
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Quality Control & Documentation
  • Purity: >85%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Mouse MFGE8 Protein contributes to phagocytic removal of apoptotic cells in many tissues. It plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. MFGE8 binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. MFGE8 promotes VEGF-dependent neovascularization.

The protein has a predicted molecular mass of 49.8 kDa after removal of the signal peptide. The apparent molecular mass of mMFGE8-His is approximately 55-70 kDa due to glycosylation.


Accession: P21956

Endotoxin < 1 EU/μg

Lyophilized from sterile PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 1 months.
References

[1] Yuheng Lu et al. Cell Death Dis. MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway

[2] Tian Tian et al. Theranostics. Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia

[3] Kehong Chen et al. J Immunol. Inhibition of Efferocytosis by Extracellular CIRP-Induced Neutrophil Extracellular Traps

[4] Yong-Yue Gao et al. Exp Neurol. MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization

[5] Ke-Qiong Deng et al. Hypertension. Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway

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Keywords: Recombinant Mouse MFGE8 Protein (HEK293, C-6×His), MFGM supplier, Other Proteins, inhibitors, activators

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