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Human High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 30 kDa, 215 amino acid (a.a.) single chain polypeptide. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins.
Accession: P09429
Molecular Weight: Approximately 26.0 kDa
Endotoxin < 1 EU/μg
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage | Stored at ≤ -20°C, stable for up to 6 months after receipt. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
[4] Ben Lu, et al. Nature. Novel role of PKR in inflammasome activation and HMGB1 release
[5] A Tesniere, et al. Oncogene. Immunogenic death of colon cancer cells treated with oxaliplatin
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