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Quinpirole Hydrochloride

Cat. No. M13950
Quinpirole Hydrochloride Structure

(-)-LY 171555

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 255.79
CAS Number 85798-08-9
Purity >99%
Solubility Water 50 mg/mL
DMSO 27.78 mg/mL
Storage 2-8°C, dry, sealed

[1] Debora Dreher Nabinger, et al. Long-lasting behavioral effects of quinpirole exposure on zebrafish

[2] Hiroyoshi Inaba, et al. The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats

[3] Dbora Dreher Nabinger, et al. Feeding status alters exploratory and anxiety-like behaviors in zebrafish larvae exposed to quinpirole

[4] Yawen Ao, et al. Application of quinpirole in the paraventricular thalamus facilitates emergence from isoflurane anesthesia in mice

[5] W Koller, et al. Quinpirole hydrochloride, a potential anti-parkinsonism drug

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Keywords: Quinpirole Hydrochloride, (-)-LY 171555 supplier, Dopamine Receptor, inhibitors

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