Free shipping on all orders over $ 500

Quinpirole Hydrochloride

Cat. No. M13950
Quinpirole Hydrochloride Structure
Synonym:

(-)-LY 171555

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.

Chemical Information
Molecular Weight 255.79
CAS Number 85798-08-9
Solubility (25°C) Water 50 mg/mL
DMSO 27.78 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Debora Dreher Nabinger, et al. Long-lasting behavioral effects of quinpirole exposure on zebrafish

[2] Hiroyoshi Inaba, et al. The dopamine D2 agonist quinpirole impairs frontal mismatch responses to sound frequency deviations in freely moving rats

[3] Dbora Dreher Nabinger, et al. Feeding status alters exploratory and anxiety-like behaviors in zebrafish larvae exposed to quinpirole

[4] Yawen Ao, et al. Application of quinpirole in the paraventricular thalamus facilitates emergence from isoflurane anesthesia in mice

[5] W Koller, et al. Quinpirole hydrochloride, a potential anti-parkinsonism drug

Related Dopamine Receptor Products
Cyclo(glycyl-L-leucyl)

Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity.

Onzigolide

Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors.

CVL-871

CVL-871 is a partial agonist at dopamine D1/5 receptors and may be used in dementia-related studies.

Paliperidone palmitate

Paliperidone palmitate is the ester precursor compound of Paliperidone, a potent dopamine antagonist and 5-HT2A antagonist. Paliperidone is a potent dopamine antagonist and 5-HT2A antagonist.

Melevodopa

Melevodopaa is an oral precursor compound to Levodopa that enters the body and can pass through the gut and blood-brain barrier into the brain. In the brain, Melevodopa is converted to dopamine, which increases dopamine levels in the brain and can be used in studies related to Parkinson's disease.

  Catalog
Abmole Inhibitor Catalog




Keywords: Quinpirole Hydrochloride, (-)-LY 171555 supplier, Dopamine Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.