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Pyronaridine tetraphosphate

Cat. No. M9462
Pyronaridine tetraphosphate Structure
Synonym:

Pyranoridine phosphate

Size Price Availability Quantity
50mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Pyronaridine tetraphosphate is a Mannich base anti-malarial with demonstrated efficacy against compound.

Chemical Information
Molecular Weight 910.03
Formula C29H44ClN5O18P4
CAS Number 76748-86-2
Solubility (25°C) acetic acid: 5 mg/mL
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shimaa Abd El-Salam El-Sayed, et al. Impact of using pyronaridine tetraphosphate- based combination therapy in the treatment of babesiosis caused by Babesia bovis, B. caballi, and B. gibsoni in vitro and B. microti in mice

[2] Sanjeev Krishna, et al. Repurposing Antimalarials to Tackle the COVID-19 Pandemic

[3] Thomas R Lane, et al. Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig

[4] Thomas R Lane, et al. Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection

[5] Joseph Pryce, et al. Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria

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