Free shipping on all orders over $ 500


Cat. No. M20998

All AbMole products are for research use only, cannot be used for human consumption.

PMX-53 Structure

3D53; PMX53; Ac-Phe-[Orn-Pro-dCha-Trp-Arg]

Size Price Availability Quantity
1mg USD 140  USD140 In stock
5mg USD 240  USD240 In stock
10mg USD 390  USD390 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PMX-53 is a potent CD88 (C5aR) antagonist with an IC50 of 20 nM, it inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects.

Chemical Information
Molecular Weight 896.09
Formula C47H65N11O7
CAS Number 219639-75-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Water 5 mg/mL (ultrasonic and warming)
Storage Store at ≤ -20°C, protect from light, dry, sealed

[1] Yubo Hou, et al. In Vitro Cell Dev Biol Anim. Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway

[2] George Hajishengallis, et al. Adv Exp Med Biol. Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches

[3] Haihui Wu, et al. Prog Histochem Cytochem. The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2)

[4] Hariharan Subramanian, et al. Mol Pharmacol. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells

[5] E Ting, et al. Br J Pharmacol. Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain

[6] Jrg Khl. Curr Opin Mol Ther. Drug evaluation: the C5a receptor antagonist PMX-53

Related Complement System Products

P014 is a C5 antibody/CFH fragment fusion protein that can be used in studies related to paroxysmal sleep hemoglobinuria (PNH) and thrombotic microangiopathy (TMA).


POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation.


TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM).


N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative.

C5a Receptor agonist, mouse, human

C5a Receptor agonist, mouse, human is a biological active peptide.

Abmole Inhibitor Catalog

Keywords: PMX-53, 3D53; PMX53; Ac-Phe-[Orn-Pro-dCha-Trp-Arg] supplier, Complement System, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.