Certificate of Analysis
| Product Name: | PMX-53 |
| Catalog Number: | M20998 |
| CAS Number: | 219639-75-5 |
Physical and Chemical Properties
| Formula: | C47H65N11O7 |
| Molecular Weight: | 896.09 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL; Water 5 mg/mL (ultrasonic and warming) |
| Storage: | Store at ≤ -20°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | PMX-53 is a potent CD88 (C5aR) antagonist with an IC50 of 20 nM, it inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |