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EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects.
| Molecular Weight | 659.6 |
| Formula | C26H32Cl2N6O6S2 |
| Form | Solid |
| Solubility (25°C) | DMSO 200 mg/mL (ultrasonic) |
| Storage | -20°C, dry, sealed |
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