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AMY-101 acetate

Cat. No. M10084
AMY-101 acetate Structure

Cp40; AMY101 acetate

Size Price Availability Quantity
1mg USD 360  USD360 In stock
5mg USD 820  USD820 In stock
10mg USD 1240  USD1240 In stock
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Quality Control & Documentation
Biological Activity

AMY-101 acetate is a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM). AMY-101 (Cp40) can improve the periodontal condition of NHPs with natural chronic periodontitis.

Chemical Information
Molecular Weight 1849.16
Formula C85H121N23O20S2
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Sara Mastaglio, et al. Clin Immunol. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

[2] Tetsuhiro Kajikawa, et al. Mol Ther Methods Clin Dev. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates

[3] Dimitrios C Mastellos, et al. Trends Immunol. Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery

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Keywords: AMY-101 acetate, Cp40; AMY101 acetate supplier, Complement System, inhibitors, activators

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