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AMY-101 acetate is a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM). AMY-101 (Cp40) can improve the periodontal condition of NHPs with natural chronic periodontitis.
| Molecular Weight | 1849.16 |
| Formula | C85H121N23O20S2 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related Complement System Products |
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| JPE-1375
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice. |
| C5aR-IN-1
C5aR-IN-1 is a potent inhibitor of C5aR. |
| EG01377 dihydrochloride
EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. |
| Empasiprubart
Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. |
| Avacincaptad pegol sodium
Avacincaptad pegol (ARC1905) is an anti-C5 RNA aptamer that inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. |
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