Free shipping on all orders over $ 500

AMY-101 acetate

Cat. No. M10084
AMY-101 acetate Structure
Synonym:

Cp40; AMY101 acetate

Size Price Availability Quantity
1mg USD 360  USD360 In stock
5mg USD 820  USD820 In stock
10mg USD 1240  USD1240 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

AMY-101 acetate is a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM). AMY-101 (Cp40) can improve the periodontal condition of NHPs with natural chronic periodontitis.

Chemical Information
Molecular Weight 1849.16
Formula C85H121N23O20S2
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sara Mastaglio, et al. Clin Immunol. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

[2] Tetsuhiro Kajikawa, et al. Mol Ther Methods Clin Dev. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates

[3] Dimitrios C Mastellos, et al. Trends Immunol. Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery

Related Complement System Products
BR103

BR103 is a C3aR-specific small molecule ligand.

3-Phenoxybenzaldehyde

3-Phenoxybenzaldehyde has weak complement classical pathway inhibition and hemolytic activity.

NH2-C6-ARC186

NH2-C6-ARC186 is a modified ARC186 with NH2-C6 that can be coupled to other peptides or molecules.

Zilucoplan TFA

Zilucoplan TFA (RA101495) is a 15 amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor that specifically targets C5, a component of the terminal complement activation pathway, thereby preventing the cleavage of C5 by C5 converting enzyme to complement components C5a and C5b, and thus preventing the downstream assembly and activity of the membrane attack complex (MAC). Can be used in studies related to immune-mediated necrotizing myopathy (IMNM) and generalized myasthenia gravis (gMG).

Complement C1s-IN-1

Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: AMY-101 acetate, Cp40; AMY101 acetate supplier, Complement System, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.