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Abmole Inhibitor Catalog 2017

Complement System Complement System

Inhibitors

Cat.No.  Name Information
M10317 LNP023 hydrochloride (Iptacopan HCl) Iptacopan (LNP023) hydrochloride is a first-in-class orally bioavailable, highly potent and selective complement factor B inhibitor with an IC50 value of 10 nM.
M10145 Danicopan (ALXN2040) Danicopan (ALXN2040; ACH-4471; ACH-0144471) is a highly potent, orally active Factor D inhibitor.
M10140 TLQP-21 TFA TLQP-21 is a VGF-derived peptide, which protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes.
M10114 PMX 205 Trifluoroacetate PMX 205 Trifluoroacetate is a potent complement antagonist of C5a (C5aR; CD88) receptor.
M9199 Avacopan Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor inhibitor with an IC50 of 0.1 nM.
M8983 Compstatin Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
M1598 Eculizumab Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5.


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