| Cat.No. | Name | Information |
|---|---|---|
| M9199 | Avacopan | Avacopan (CCX168) is a first-in-class, potent, selective and orally available complement 5a receptor (C5aR1 or CD88) antagonist with an IC50 of 0.1 nM. |
| M10140 | TLQP-21 TFA | TLQP-21 is a VGF-derived peptide, which protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes. |
| M10114 | PMX 205 Trifluoroacetate | PMX 205 Trifluoroacetate is a potent complement antagonist of C5a (C5aR; CD88) receptor. |
| M10084 | AMY-101 acetate | AMY-101 acetate is a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM). |
| M8983 | Compstatin | Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. Compstatin exhibits exclusive specificity for primate C3s and does not bind either to C3s from lower mammalian species or to two structural homologs of C3, human C4 and C5. |
| M8470 | SB290157 trifluoroacetate salt | SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells. |
| M1598 | Eculizumab | Eculizumab is a first-in-class recombinant humanized monoclonal antibody targeting complement protein C5. C5, which can only recognize humans, cannot bind to C5 of other species. |
| M56344 | C5aR-IN-1 | C5aR-IN-1 is a potent inhibitor of C5aR. |
| M56343 | EG01377 dihydrochloride | EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. |
| M55571 | Empasiprubart | Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. |
| M55560 | Avacincaptad pegol sodium | Avacincaptad pegol (ARC1905) is an anti-C5 RNA aptamer that inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. |
| M54558 | P014 | P014 is a C5 antibody/CFH fragment fusion protein that can be used in studies related to paroxysmal sleep hemoglobinuria (PNH) and thrombotic microangiopathy (TMA). |
| M52862 | TLQP-21 | TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). |
| M52861 | N-((Allyloxy)carbonyl)-N-methyl-L-alanine | N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. |
| M52860 | C5a Receptor agonist, mouse, human | C5a Receptor agonist, mouse, human is a biological active peptide. |
| M52859 | C5a Anaphylatoxin (human) | C5a Anaphylatoxin (human) is a pro-inflammatory peptide and a leukocyte chemoattractant. |
| M45389 | Avacincaptad pegol | Avacincaptad pegol is a nucleic acid aptamer and inhibitor of C5 complement that reduces inflammation-associated retinal pigment epithelial (RPE) damage.Avacincaptad pegol can be used to study stargardt macular dystrophy (STGD1) and geographic atrophy (GA). |
| M41964 | BR103 | BR103 is a C3aR-specific small molecule ligand. |
| M41963 | 3-Phenoxybenzaldehyde | 3-Phenoxybenzaldehyde has weak complement classical pathway inhibition and hemolytic activity. |
| M41962 | NH2-C6-ARC186 | NH2-C6-ARC186 is a modified ARC186 with NH2-C6 that can be coupled to other peptides or molecules. |
| M41961 | Zilucoplan TFA | Zilucoplan TFA (RA101495) is a 15 amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor that specifically targets C5, a component of the terminal complement activation pathway, thereby preventing the cleavage of C5 by C5 converting enzyme to complement components C5a and C5b, and thus preventing the downstream assembly and activity of the membrane attack complex (MAC). Can be used in studies related to immune-mediated necrotizing myopathy (IMNM) and generalized myasthenia gravis (gMG). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
